Minoxidil (Regeyn, Rogain)
Frequent appointment with alopecia areata remains steroid therapy. The use of glucocorticosteroids (GCS), both local and general, not justified in all cases. It is known that the GCS often anti-inflammatory, anti allergic and immunosuppressive properties. They successfully applied for the treatment of autoimmune diseases, but do not have the selectivity of suppressive action. The large number of GCS Diprospan occupies a special place, which is used by injection in the lesions. Obkalyvaniya centers are usually scheduled at intervals of 1 times in 1 - 2 weeks for several months, which may lead to hormonal dependence and complications. Despite the fact that the therapeutic effect occurs at a sufficiently large percentage of patients, this method is contraindicated in children and adolescents. Our observations on the application of GCS allow hormone therapy, but with the strict observance of certain conditions:
Age of patients must be over 15 years
The way the introduction of GMP should be transdermal (no injection)
Applying SCS appropriate only for fresh foci, whose age is less than 2 months
Use the GCS in the active phase of alopecia (intensive growth centers)
In the presence of serious comorbidities, requiring the use of GCS In alopecia with a long history and conservative movement (most total and universal stage) the use of GCS, in our view, makes no sense. From the local side effects of hormone therapy may atrophy of the skin structures, hypopigmentation, Regionarnoe swollen lymph nodes, allergy in the form of itching, and vesicular rash. In the mid 80-ies in the U.S. for the treatment of alopecia was applied Minoxidil (Regeyn, Rogain). This drug has a vasodilator effect and is used mainly in men with androgen form. The therapeutic effect of minoxidil in alopecia areata is highly questionable, even with prolonged use it. Expansion of the vascular network of the skin resulting in increased capillary permeability, which makes it difficult for an autoimmune process with alopecia areata, especially in immunoreactive phase.
